Mechanism of Cholestasis

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Management of Hepatic Cholestasis

Hepatic cholestasis is characterized by elevated alkaline phosphatase and gama - glutamyl transpeptidase levels which is then followed by conjugated hyperbilirubinemia. It is classified into intrahepatic and extrahepatic cholestasis. Intrahepatic cholestasis indicates hepatocellular dysfunction or the presence of an obstructive lesion in intrahepatic bile ducts distal to biliary canalicular sy...

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Diagnosis of Neonatal Cholestasis

Cholestasis is frequent in neonates (1/2,500 live births) and in young children. It includes many etiologies with sometimes poor prognosis. In case of neonatal cholestasis, the most important point is to look at the stool color and to rule out biliary atresia which needs to be surgically treated before the 45th day of life. Biliary atresia represents almost 50% of cases of neonatal cholestasis,...

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Intrahepatic cholestasis of pregnancy.

Intrahepatic cholestasis of pregnancy is the most common pregnancy-specific liver disease that typically presents in the third trimester. The clinical features are maternal pruritus in the absence of a rash and deranged liver function tests, including raised serum bile acids. Intrahepatic cholestasis of pregnancy is associated with an increased risk of adverse perinatal outcomes, including spon...

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Neonatal cholestasis.

2004;25;388 Pediatrics in Review Frederick J. Suchy Neonatal Cholestasis http://pedsinreview.aappublications.org/content/25/11/388 located on the World Wide Web at: The online version of this article, along with updated information and services, is http://pedsinreview.aappublications.org/content/suppl/2005/01/26/25.11.388.DC1.html Data Supplement (unedited) at: Pediatrics. All rights reserved. ...

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EVALU ATI ON OF THE CAUSES OF CHOLESTASIS IN INFANTS

During a period of three years from 1996 to 1998, 124 infants (64 male and 60 female) with an age range of 1-6 months (mean age 1.5 months) with cholestasis were studied. Idiopathic neonatal hepatitis was the most common cause of cholestasis, accounting for 48 cases with a rate of 3'8.70% in a total of 124 patients, followed by galactosemia in 29 patients (23.38%) and extrahepatic biliary ...

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ژورنال

عنوان ژورنال: Gastroenterology

سال: 1972

ISSN: 0016-5085

DOI: 10.1016/s0016-5085(19)33226-3